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Weight-Related Outcomes and Adiposity Metrics In the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial [61], semaglutide reduced major adverse cardiovascular events by 20% in adults with cardiovascular disease, overweight or obesity, and no diabetes

Sirohi et al., 2017a

However, real-world patient data suggests evening injection correlates with better early adherence due to reduced daytime nausea, though long-term outcomes are equivalent regardless of timing

For individuals with pre-existing non-alcoholic fatty liver disease, weight loss of this magnitude often produces measurable hepatic improvement

Clinical success stories and celebrity endorsements have raised public awareness, boosting off-label demand

Also see the evidence for use by older men and women in our Magnesium Supplements Review