Importantly, bi-functionalization significantly enhances BBB permeability in vitro and in vivo by up to five-fold compared to mono-functionalized liposomes because of the optimized size ( 2x) and 46% release at pH 5.5, facilitating cytosolic delivery, while being stable at pH 7.4
[PubMed] [Google Scholar] 177.Kopets R., Kuibida I., Chernyavska I., Cherepanyn V., Mazo R., Fedevych V., Gerasymov S
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