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Eur J Clin Pharmacol

A balanced approach to health and wellness is essential

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Nrf2 Pathway Activation Glutathione depletion triggers activation of Nrf2 (nuclear factor erythroid 2-related factor 2), the master transcription factor for antioxidant gene expression

The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions

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