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Notably, DNA damage and subsequent genome instability are major driving forces for tumorigenesis and aging via driving mutation

You start feeling fatigued

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J Interferon Cytokine Res 31:653659 Malaguarnera M, Vacante M, Giordano M, Pennisi G, Bella R, Rampello L, Malaguarnera M, Li Volti G, Galvano F (2011) Oral acetyl-l-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study