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Receptor engagement initiates a cAMP/PKA signaling cascade in pancreatic beta cells and activates GLP-1 receptors expressed in hypothalamic appetite-regulating centers, including the arcuate nucleus

Pharmacol Rev 2016;68:9541013.ArticlePubMedPMC 40

To investigate the effect of RRM2 on the cell cycle of THCA, we examined the effects of RRM2 knockdown ( RRM2 -KD) and overexpression ( RRM2 -OE) on cell cycle distribution in the TPC-1 and IHH4 cell lines, respectively, using flow cytometry

These include altered firing activity of dopaminergic neurons and/or other mechanisms that modify DA release

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