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Patients were commenced on tirzepatide 2.5 mg, and this was escalated every four weeks by 2.5 mg to a maximum tolerated dose of 10 mg or 15 mg weekly

10.12691/ajmbr-2-6-2 141 NaseerF.AhmedM.MajidA.KamalW.PhullA

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In a study published in 2017, the long-term use of metformin (Glucophage), an anti-diabetic medication, was correlated with a lower risk of gallstones in diabetic subjects (Liao 2017)

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The potential of GLP-1RAs to induce psychiatric adverse events is biologically plausible given the widespread expression of GLP-1 receptors in the central nervous system, 167 their influence on neurocognitive function, 168 and their effects on inflammation, stress response, and energy metabolism, which theoretically could improve mood