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A case report of a patient with HER2-expressing NEPC with rapid progression on seven different lines of therapy demonstrated substantial response on off-label treatment with T-DXd, including a 57% overall reduction in tumor volume across sites of metastases and improved performance status 171

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A previous meta-analysis of randomised trials demonstrated that supplementation with green tea extract resulted in a larger reduction in body weight in participants with obesity (MD: 253 kg) as compared to participants who were overweight (MD: 107 kg) and normal weight (MD: 028 kg) (Reference Lin, Shi and Su9)

BOX 7-3 Proposed Characteristics of Congenital Melanocytic Nevi That Increase Risk for Malignancy Size Number of medium CMN Location Number of satellite nevi by 1 year of age Heterogeneity of color Rugosity Hypertrichosis Extensive nodules Adapted from Krengel, S., Scope, A., Dusza, S.W., Vonthein, R., & Marghoob, A

Phase I awards have budgets of up to $200,000