El Glutatin (GSH) es el antioxidante endgeno ms abundante del cuerpo, compuesto por glutamato, cistena y glicina
GSSG, oxidized glutathione
Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191-214. doi:10.1515/BC.2009.033
In the current study, the Y113 residue plays a crucial role for the haem-dependent dimerization of PGRMC1 and resultant regulation of cancer proliferation and chemoresistance (Figs 5c and 6e)
The most important determinant of this compartmentalization is the polyglutamate tail
Helicobacter pylori induced gastric inflammation, ulcer, and cancer: A pathogenesis perspective