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SQSTM1 is known as an ubiquitin-binding protein and promotes the aggregation of cullin3-modified caspase-8 within p62-dependent foci, leading to cell apoptosis 50

The randomization was single-blinded for the clinical research team and the referring obstetrician

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(2022) Long-term stable disease in a rectal-cancer patient treated by methionine restriction with oral recombinant methioninase and a low-methionine diet, Anticancer Res