When you lose weight and your skin sags, the underlying problem is often that the collagen network has been stretched, damaged, or degraded beyond what the body can repair at its natural pace
These pigmented lesions do not normally pose serious health risks
However, several melanocytomas arise de novo (without a pre-exsisting common nevus): for example, cases of pure (non-combined) PEM are also genetically peculiar because often they harbor kinase (most commonly PRKA , but also NTRK1 and NTRK3 ) (38) fusions as the initiating event
However, the market faces challenges
More serious but less common adverse effects include pancreatitis, gallbladder disease, and hypoglycemia (particularly when combined with insulin or sulfonylureas)
Focusing on such molecules, along with promising therapeutic candidates like Epigallocatechin gallate and tofacitinib, offers encouraging strategies for targeted interventions in RM (Xie et al., 2024)