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Oral fucoxanthin (10 mg/kg) reduced experimentally UVB-induced skin pigmentation in guinea pigs, probably due to suppression of proinflammatory cytokine prostaglandin E2 (PGE2) synthesis and receptors involved in melanogenesis [85]

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In the stage of cancer progression, administration of high doses of vitamin C, especially in combination with redox-active metals (copper, iron) may increase the cellular prooxidant state triggering cytotoxicity of cancer cells (Pawlowska et al