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Nature 420 , 333336 (2002)

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These early immunotherapies were non-specific, however within the past decade the utilization of targeted immunotherapies have risen with monoclonal antibodies that block immune checkpoint molecules, such as cytotoxic T-lymphocyte associated protein4 (CTLA-4), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1), adoptive T-cell therapies and oncolytic viruses (151, 153155)

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