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Abbreviations ABCG2 ATP-binding cassette transporter G2 Akt Protein kinase B AMPK AMP-activated protein kinase BMP4 Bone morphogenetic protein 4 cAMP Cyclic adenosine monophosphate cas-3 Caspase-3 CDK2 Cyclin-dependent kinase 2 c-Myc Myelocytomatosis oncogene CRC Colorectal cancer CREB CAMP-response element binding protein DPP-4 Dipeptidyl peptidase IV E-cad E-cadherin ECM Extracellular matrix EGFR Epidermal growth factor receptor ENZ Enzalutamide EMT Epithelial-mesenchymal transition ERK Extracellular signal-regulated kinase Ex-4 Exendin-4 FGFR Fibroblast growth factor receptor GIP Glucose-dependent Insulinotropic Polypeptide GLP-1 Glucagon-like peptide-1 GLP-1RAs Glucagon-like peptide-1 receptor agonists GPCR G-protein-coupled receptor GSK3 Glycogen Synthase Kinase 3 HPV-16E7 Human papillomavirus type 16 E7 protein ICAM-1 Intercellular adhesion molecule-1 IGF Insulin-like growth factor IL Interleukin LC3I/II Microtubule-associated proteins light chain 3I/II LNG-IUD Levonorgestrel-releasing intrauterine device MAPK Mitogen-activated protein kinases MMP Matrix metalloproteinase mTOR Mammalian target of rapamycin NAFLD Non-alcoholic fatty liver disease NASH Non-alcoholic steatohepatitis NETs Neutrophil extracellular traps NF-B Nuclear factor kappa B PGR Progesterone receptor PI3K Phosphatidylinositol-4,5-bisphosphate 3-kinase PKA Protein kinase A PSC Pancreatic stellate cell RCTs Randomized controlled trials RhoA Rho-associated kinase ROS Reactive oxygen species S6K1 Ribosomal s6 kinase 1 SDF-1 Stromal cell-derived factor-1 SGLT2 Sodium-dependent glucose transporters 2 SKP2 S-phase kinase-associated protein-2 STAT3 Signal transducer and activator of transcription 3 T2DM Type 2 diabetes mellitus TGF- Transforming growth factor-beta TIMP Tissue inhibitor of metalloproteinase TNF- Tumor necrosis factor-alpha TZD Thiazolidinediones VCAM-1 Vascular cell adhesion molecule-1 VEGF Vascular endothelial growth factor Authors contributions Writing-original draft, A.Q.L., Y.X.D., Z.R.L., A.M.J., Z.Q.L., W.Z.H., C.Q., J.Z., P.L

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