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The authors concluded that patients allergic to sulfonamide antibiotics are likely predisposed to further allergic reactions with other drugs, rather than specifically to sulfa-based medications

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In the acute phase, BBB disruption is primarily triggered by the initial insult, with energy depletion causing ion pump dysfunction, leading to cytotoxic edema and the activation of multiple enzymatic pathways (165)

J Autism Dev Disord 2012

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