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Additionally, electrophysiological data showed that modification of Cys residues with NEM blocked the decrease in ENaC P o when channels were directly exposed to GSSG in the recording electrode (Fig

Thus, the disruptions of the kidney-brain axis contribute to the high morbidity of neurological disorders, such as cognitive impairment in CKD (Yan et al., 2024)

Halczuk KM, Boguszewska K, Urbaniak SK, Szewczuk M, Karwowski BT

However, factors like poor diet, stress, pollution, and aging can deplete glutathione levels

Rainey RP, Gillman IG, Shi X, Cheng T, Stinson A, Gietl D, Albino AP: Fluorescent detection of lipid peroxidation derived protein adducts upon in-vitro cigarette smoke exposure

Pharmacol Rev 54:271284 Gras G, Porcheray F, Samah B, Leone C (2006) The glutamate-glutamine cycle as an inducible, protective face of macrophage activation