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In this context, the activation of PPARs by novel therapeutics like GW0742 is emerging as a relevant tool to manage liver stress by modulating hepatic energy metabolism and several altered metabolic routes usually disrupted in obesity, but these effects remain to be elucidated (Schuppan & Schattenberg, 2013)

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61 GLP-1R activation triggers Gs-protein coupling, elevating cAMP, modulating calcium mobilization, and inducing -arrestin recruitment

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Refrigeration of the product may cause darkening of the solution due to the riboflavin content