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American Heart Journal 2022, 254: 12-22

Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604

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Every other day feeding caused a reductive shift in the pyruvate/lactate in female mice cerebral cortex, but not in this region in male mice (Sorochynska et al., 2019)