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Functionally verifying the incretin receptor-dependent nature of the molecule, GLP-1GIPLani decreased body weight, food intake and blood glucose in DIO wild-type mice, and these effects were absent in DIO DIR-knockout mice (Fig

M., Ciampelli, M., Muzj, G., Belosi, C., Selvaggi, L., Ayala, G.F., and Lanzone, A