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For example, after GLP-1 binding the transmembrane helices 1 (TM1) rotates clockwise when looking down the membrane helices from the extracellular face (see TM1 marked in Figure 6) and a kink is introduced in the transmembrane helix 6 (TM6), as is typical for all class B1 GPCRs

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Theranostics 6(12):2015 Sobu A, Machaliski B (2016) Trophic factors in the therapeutic challenge against ALS: current research directions

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