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Evidence strength adapted from Oxford Centre for Evidence-Based Medicine levels

Toxins 8 (6), 173

Mitochondrial-targeted nanodrugs enhance drug delivery to the mitochondria, amplifying therapeutic effects while minimizing collateral damage to healthy cells

Many cytokines that play a role in RA transmit signals through the JAK/STAT pathway (51)

Multiple endocrine neoplasia syndrome type 2 carries similar restrictions

These data show that in vivo models do not fully reflect the range of symptoms associated with Fabry disease, presumably owing to their relatively short lifespan compared to humans