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91 In addition to the above-mentioned biological effects, MITF expression can also dictate the sensitivity of BRAF -mutant melanoma to MAPK- inhibition-targeted therapy, though the role is paradoxical in terms of the phase of drug resistance establishment

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The intranasal administration of GHK-Cu represents a novel approach aimed at overcoming the challenge of bypassing the blood-brain barrier, a common hurdle in traditional targeted neurotherapeutics [14-16]

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