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16 , 47 However, a reliable estimation can be made by comparing brain uptake after intranasal and intravenous administration

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Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6

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10.1038/ncponc0740 173 SchnfeldK.HerbenerP.ZuberC.HderT.BernsterK.UherekC.et al (2018)