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Moreover, it reduces free radical production by suppressing cytochrome P450 enzyme activity.16 Growing evidence indicates that melatonin exerts significant protective effects on reproductive tissues through its potent antioxidant and anti-apoptotic properties.17-19 Experimental studies in both female and male models have shown that melatonin reduces oxidative stress markers, preserves follicular and testicular structure, and ameliorates apoptosis-related damage.18 In this study, the potential protective effects of Mel and GSH were investigated against CARB-induced ovarian damage in rats
Given the high oxidative sensitivity of reproductive tissues, this points toward applications in both aging and fertility preservation
Hydrophobic and basic residues at the P 2 position enhance the affinity for cleavage compared with acidic residues (Reference Power, Nongonierma and Jakeman94)
