Detection and purification of backbone-cyclized proteins using a bacterially expressed anti-myc-tag single chain amtibody
Secondary endpoints included changes in total alcohol intake, number of drinks per day, number of days without alcohol intake, alcohol craving, plasma enzymes, body weight, hemoglobin A1c (HbA1c), waist circumference, and self-reported measures of quality of life and health, among others
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Across 2,339 adults with obesity or overweight, all three doses of retatrutide met the primary and key secondary endpoints at 80 weeks
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Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has demonstrated significant weight loss benefits in clinical trials, with patients losing an average of 15% of body weight over 68 weeks
