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For bloating and distension, a large meta-analysis of 82 trials found combination probiotics and Bacillus strains showed benefit, though the authors rated the overall certainty of evidence as low, so this is best framed as "some evidence," not a guarantee
Also, the combination strategy is classified as either an add-on therapy or a simultaneous initiation of both medications
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Nature 618 , 402410 (2023)
Shah PK, Lecis D
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