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Compared with other antidiabetic medications, GLP-1RAs provide better glycemic control with the additional benefit of weight loss

3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%

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Choy TK, Wang CY, Phan NN, Khoa Ta HD, Anuraga G, Liu YH, et al

A yet further aspect of the invention provides the use of the human antibodies of the invention or an antigen-binding fragment or immunoconjugate of such an antibody in the manufacture of a composition or medicament for use in therapy, imaging or diagnosis