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A 2025 meta-analysis in Diabetes, Obesity and Metabolism confirmed that across SURMOUNT-1 to -4, GI adverse events with tirzepatide ranged from 27.8% to 72.8% (any GI event) versus 12.2% to 32.5% on placebo, with discontinuation due to GI symptoms running 1.0% to 10.5%
March 13, 2025
If required, gently pinch a fold of skin between thumb and forefinger to lift the subcutaneous layer away from underlying muscle
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