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Identification of UNC10415667, a benzaldehyde containing NSD2 degrader While UNC10088 and UNC8732 are promising cell-free and cell-based tool compounds, respectively, we were interested in developing non-prodrug analogs that could similarly engage FBXO22 to promote NSD2 degradation without requiring bioactivation for activity

Why did the lower dose work better than the higher dose

We observed that lipid ROS were induced only in cells which were depleted of both cystine and GSH and the induction was prevented by Fer-1 (Fig

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Endogenous collagen is natural collagen, manufactured by the body

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