In the TCA, succinate is oxidized to fumarate and then hydrated to malate through the activity of two enzymes, succinate dehydrogenase, and fumarase
In clinical trials, people lost an average of 14.9% of their initial body weight over 68 weeks
Volume-driven habits are giving way to smaller, smarter, more intentional consumption
Although WHO advisory committee had initially judged the evidence as inconclusive, after the EMA took more decisive action, both regulatory authorities concluded that NAION should be classified as a very rare (up to 1 in 10,000 users per year) side effect of semaglutide and recommended discontinuation of the drug if NAION is confirmed
The FDA gives temporary authorization for compounding pharmacies to produce drugs on the shortage list
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