Excess heat reduces preservative strength within stored vials
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The top hits include Trp-catabolism the OVX animals plasma showed high level of KYN and that was reduced by EB-treatment, the KYN/Trp ratio was significantly high in the OVX animal compared to the OVX+E2 treated group
Plasma clearance rates for trimethylamines were also determined, and observed to be within a factor of 2 of one another, with elimination of BB being faster than that of either TMA or TMAO (Figure S2)
It is a statement about where the evidence currently stands