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In a retrospective analysis of ninety-day toxicity study data from eighty-three mouse studies and eighty-seven rat studies that were also tested for carcinogenicity, the combined presence of hepatocellular necrosis, hepatocellular hypertrophy, hepatocellular cytomegaly, bile duct hyperplasia, and hepatocellular degeneration, along with increased liver weight, was significantly predictive of hepatocarcinogenicity in the two-year study (Allen et al

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At week 12, there were no significant differences found between the treatment and placebo groups in terms of the total number of UV spots, spot polarization, or measurements of skin tone

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Combined mycophenolate + prednisolone therapy is more effective than prednisolone in active and moderate-to-severe Graves Orbitopathy a randomized, observer blind, multicenter trial

doi:10.1016/s2213-8587(18)30104-9