This chronic, systemic depletion allows environmental toxins and latent, dormant infections (such as EBV or human herpesviruses) to reactivate and accumulate, continuously driving immune dysfunction, mast cell activation syndrome (MCAS), and unrelenting fatigue
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NAC may rarely cause bronchospasm in people with asthma
Abbreviations PD: Parkinsons disease CNS: Central nervous system SCFA: Short-chain fatty acid TLR: Toll-like receptor LPS: lipopolysaccharide BBB: Bloodbrain barrier HDAC: Histone deacetylase REM: Rapid eye movement SNpc: Substantia nigra pars compacta ENS: Enteric nervous system GI: Gastrointestinal ROS/RNS: Reactive oxygen and nitrogen species FMT: Fecal microbiota transplantation GALT: Gut-associated lymphoid tissue AHR: Aryl hydrocarbon receptor SAAs: Seed-amplification assays TNF-: Tumor necrosis factor-alpha References Su D, Cui Y, He C, Yin P, Bai R, Zhu J, et al
Slavin YN, Asnis J, Hfeli UO, Bach H
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