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The Florida Weight-Loss Consumer Bill of Rights, posted on TeleHealth Med's site, notes that rapid weight loss of more than 1.5-2 lbs per week may cause serious health problems

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FASEB J 28 , 23982413, (2014)

A number of different -cell markers, including glucagon-like peptide-1 (GLP-1) receptors, sulfonylurea receptors, vesicular amine transporter 2, and gangliosides have been used as targets for labeling [16]