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however, it could impair endothelial function via down-regulation of ACE2 and disrupt the integrity of BBB 284,285

Summar ML, Koelker S, Freedenberg D, Le Mons C, Haberle J, Lee HS, Kirmse B (2013) The incidence of urea cycle disorders

Some patients achieve their glycaemic targets and substantial weight loss, leading their healthcare team to consider whether continued treatment remains necessary