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When NK cells are activated, they release cytotoxic granules, inducing direct tumor cell lysis

Notably, LPS-CD14 binding via pattern recognition receptors not only mediates innate immune activation but has been mechanistically linked to insulin resistance, obesity, and DM pathogenesis ( From a systems biology perspective, gut microbial metabolites serve as critical signaling mediators in gut-lung axis crosstalk, whose homeostatic disruption may reprogram metabolic-immune networks to propagate diabetic multi-organ complications

10.1136/gutjnl-2015-309800 Gut

10.1161/STROKEAHA.119.025914 150

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