The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met
Their joint consensus statement concluded that the existing literature indicates a possible small increased risk of NAION in patients taking semaglutide, but the risk remains low and is yet to be confirmed
Indeed, in January 2025, the Surgeon General of the United States released a report raising awareness of the links between cancer and alcohol consumption 4
Liposomal glutathione is generally well-tolerated with minimal side effects
[2] The lower headline number in REDEFINE 2 than in REDEFINE 1 is the expected pattern weight loss is typically smaller in populations with type 2 diabetes and is a good reminder that a trials population matters as much as its drug
What is the status quo challenge
