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Six glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs) are approved for the treatment of type 2 diabetes, including 4 long-acting agents, but only 1 (liraglutide) is approved and 1 (semaglutide) under investigation for the treatment of obesity

Several disease-associated mutant proteins are subject to regulation via both ERAD and ER-phagy, including Akita proinsulin in diabetes, 248,265,274,275 POMC C28F in early-onset obesity, proAVP G57S in diabetes insipidus, 276,277 and NPC1 I1061T in NiemannPick type C disease

GLP-1 RAs are particularly effective for promoting weight loss, controlling glycemic levels (notably A1c), and reducing the risk of strokes

To prevent movement contamination from confounding the result with 18 F-FDG uptake in muscles, isoflurane anesthesia (5% for induction and 2% for maintenance) was used here for biodistribution detection and imaging