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Most patients start with every-other-night application for the first 1 to 2 weeks to minimize irritation from tretinoin, then increase to nightly use as tolerated

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Mushrooms and several fruits and vegetables are rich sources of two common polyols, mannitol and sorbitol

The first 2.5 mg dose is primarily a tolerability dose, and clinically meaningful weight loss typically requires several weeks of consistent dosing as tirzepatide levels build in your system

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