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Sugar-free, peppermint flavored, and lighter on the gut than gels during high-intensity efforts when GI distress is most likely

This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule

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European Review for Medical and Pharmacological Sciences ( Eur Rev Med Pharmacol Sci )

When weight loss happens more gradually, the body tends to preserve more lean tissue and pull a larger percentage of that weight loss from fat stores instead

In randomized clinical trials, about 17% of patients dropped out due to side effects of semaglutide compared to 8% in the placebo group, most often due to GI problems