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In our work, the elevated fatality in male groups was highly consequential due to the increased risk of mortality-driven bias in the datathat arises when comparing a group comprised of the individuals most tolerant to treatment (APAP-treated males) with another that consists of the individuals both least and most tolerant to treatment (APAP-treated females)

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Andia I, Maffulli N

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We chose SGLT-2 inhibitors as the secondary comparator because they are also used at a disease stage similar to GLP-1 receptor agonists and have not been associated with the outcome.16 For both cohorts, we defined cohort entry as the date of the first prescription for either a GLP-1 receptor agonist or the comparator drug during the study period

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Thus, SARS-CoV-2 infection dysregulates mitochondrial metabolism and forces the host cell to generate energy (ATP) and other metabolites to support viral life cycle 38

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