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The mechanism of CHAMP activity involves the inhibition of ERK5 kinase activity and HSP90, in addition to ERK5 degradation, which should contribute to the excellent anti-tumor potency and ERK5-targeting specificity since we did not observe other kinase hits (Fig

10.1016/j.jmb.2020.05.020 107 SeneffS.KyriakopoulosA

This binding acts as a master switch, upregulating the expression of over 200 cytoprotective genes

Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression

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