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By using the specific activity of purified recombinant GSTP1, the GSTP1 protein concentration in transfected cells was estimated at 4051 g/mg cytosolic protein

[11] This becomes significant in the mechanism of action described below

GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

Furthermore, when using cholesterol hydroperoxide (ChOOH, a specific GPX4 substrate) as a stressor, compound 102 could activate GPX4 in intact cells and protect them from ChOOH toxic effects ( Supplementary Figure S12B )