Melanotan-2 failures typically result from protein denaturation caused by improper storage (temperatures above 8C post-reconstitution), incorrect dosing that falls below the melanocortin receptor activation threshold (typically 0.250.5mg daily for most users), or receptor downregulation from continuous dosing without cycling breaks
In fact, they work better together, boosting each others antioxidant effects
However, if the pain is structural (like from a slipped disc), semaglutide alone may not address the root issue
There's also the reduced food intake piece
Additionally, DPP-4 inhibitors, SGLT2 inhibitors, or insulin therapy might be appropriate alternatives, depending on the patients specific needs, preferences, and overall health status
LeClerque A, Wan H (2007) Novel dominant selection marker for the transformation of fungi