Current guidelines recommend metformin and insulin as first-line treatments4,5
is a consultant to Takeda Pharmaceuticals, receives or has received sessional fees and lecture fees from the Australian Medical Council, Therapeutic Guidelines publication, and New South Wales Institute of Psychiatry, and royalties/honoraria from Hogrefe and Huber, McGraw Hill Education, Blackwell Scientific Publications, BioMed Central and PLOS Medicine, and has received research grants from the NHMRC and ARC
The construction of all yeast strains is shown in Supplementary Table 5
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In people with T2D and overweight/obesity, 16 weeks of danuglipron led to a placebo-adjusted WL up to 4.2 kg with the highest dose of 120 mg twice daily
While GLP-1 receptor agonists may offer some cardiovascular benefits, these effects are comparable to those achieved through bariatric surgery
