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Conclusions: In this post hoc analysis, treatment with sebetralstat 600 mg ended progression of HAE attacks early, with a median of 19.8 min in KONFIDENT-S, which was consistent with results from the KONFIDENT trial (medians of 19.8 and 19.2 min for 300 mg and 600 mg sebetralstat, respectively)

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Longer exposure appeared to be detrimental or toxic to the neurons

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Kagwade, A

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