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Funding: The work was supported by the Spanish Ministry of Science and Innovation, grant number BFU2005/230 and CIBERER and grant form Generalitat Valenciana number AP-004/07

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Declining estrogen affects thermoregulation (hot flashes), mood regulation, and even melatonin receptor sensitivity

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Treatment with 5-HTP can also help increase serotonin and improve mood and panic disorders, as well as insomnia ( Overall, the conversion of tryptophan to serotonin is responsible for many of its observed effects on mood and cognition ( Summary The importance of tryptophan is likely due to its role in serotonin production

Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends