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doi: 10.1136/gutjnl-2021-326789 23 DimbaN

FIGURE 5 Antioxidant Treatment Rescues the Aggravated Spiral Ganglion Neurons Loss and Apoptosis Induced by Glutathione Peroxidase 1 Deficiency After Peroxynitrite Injury To explore whether GPX1 plays a protective role in peroxynitrite-induced SGNs damage by reducing intracellular ROS, we conducted a rescue experiment by using the antioxidant N-acetylcysteine (NAC)

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A Broad-Spectrum Melanocortin Pathway Peptide Melanotan II is a synthetic peptide that activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R) a broader pathway profile than PT-141, which acts primarily on MC4R

The incubation period is usually 34 days after the exposure, but may be as short as 1 day or as long as 10 days