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There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

Other frequent Wegovy side effects include: Diarrhea (30% of patients) Vomiting (24% of patients) Constipation (24% of patients) Abdominal pain (20% of patients) Headache (14% of patients) Fatigue (11% of patients) Managing Common Side Effects Starting with smaller meals and avoiding high-fat foods can help minimize gastrointestinal discomfort

doi: 10.1038/nature09922

If youre struggling with congestion or uneven texture, this can make a visible difference over time

Novo initially made an aggressive offer to acquire Metsera, which prompted Pfizer to raise its bid, ultimately winning the deal

But their adoption in employer benefit plans is complex