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The monoamine theory proposes that depression is caused by a decrease of the extracellular availability of noradrenaline and serotonin

May convince skeptical physician if clear objective improvements documented

At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]

Antioxidant mechanisms and cellular protection studies

The exclusion criteria included: studies unrelated to gallic acid

For pharmacies, this shift is immediately visible