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Muscle Weakness Low glutathione can lead to muscle weakness and greater fatigue during workouts

Nicotinamide for the treatment of heart failure with preserved ejection fraction

Polymorphism in glutathione S-transferase loci as a risk factor for common cancers

It interacts to the transferrin protein and participates in the trace element-dependent process during antioxidant activity

Similarly, any direct disablement of GPX4 removes the critical barrier against lipid peroxidation, thereby inducing cell death via ferroptosis (149,150)

WHO estimates that 500,000 cases of IMD occur each year, approximately 50,000 of which are fatal (Findlow et al., 2025